X0508 4 2025-10-21 0 0001599298 Summit Therapeutics Inc. SMMT 0001890784 Anand Bhaskar C/O SUMMIT THERAPEUTICS INC. 601 BRICKELL KEY DRIVE, SUITE 1000 MIAMI FL 33131 0 1 0 0 Chief Accounting Officer 0 Common Stock 2025-10-21 4 A 0 26680 18.74 A 159751 D Acquired in a private placement transaction pursuant to the terms of a definitive agreement, dated as of October 21, 2025, pursuant to which the Issuer agreed to sell shares of common stock to the Reporting Person and certain other parties at a purchase price of $18.74 per share. The transaction is anticipated to close on or about October 23, 2025. Holdings include shares previously acquired through exempt transactions pursuant to the Issuer's employee stock purchase plan. /s/ Bhaskar Anand 2025-10-23